1,3,4-Thiadiazole, 2-amino-5-methyl- → 4-Hydroxy-2-methyl-N-(5-methyl-1,3,4-thiadiazole-2-yl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide

HRID 128275

반응식

HRID 128275 반응식
[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18](OC)=[O:19].[NH2:22][C:23]1[S:24][C:25]([CH3:28])=[N:26][N:27]=1>>[OH:1][C:2]1[C:7]2[S:8][C:9]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[C:6]=2[S:5](=[O:16])(=[O:15])[N:4]([CH3:17])[C:3]=1[C:18]([NH:22][C:23]1[S:24][C:25]([CH3:28])=[N:26][N:27]=1)=[O:19]

참가 물질

3

반응물 2

HCID 669491,3,4-Thiadiazole, 2-amino-5-methyl-HCID 547072593-carbomethoxy-4-hydroxy-2-methyl-2H-[1]benzothieno[2,3-e]-1,2-thiazine 1,1-dioxide

생성물 1

HCID 867376414-Hydroxy-2-methyl-N-(5-methyl-1,3,4-thiadiazole-2-yl)-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide수율 65%

실험 절차

Prepared analogous to Example 1 from methyl 4-hydroxy-2-methyl-2H-[1] benzothieno [2,3-e]-1,2-thiazine-3-carboxylate-1,1-dioxide and 2-amino-5-methyl-1,3,4-thiadiazole with a yield of 65% of theory.

출처 및 근거

ORD 기록
ord-b6d82c9a97964d679604d209a1dd1888
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259336

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