Phosphorus pentachloride → 2-Chlorocarbonyl-6-methyl-benzo[b] thiophene-3-sulfonic acid chloride

HRID 128281노트

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HRID 128281 반응식
[C:1]([C:4]1[S:8][C:7]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:6]=2[C:5]=1[S:14]([O-:17])(=O)=[O:15])(O)=[O:2].[Na+].P(Cl)(Cl)(Cl)(Cl)Cl.[Cl-:25].[Cl-:26].[Cl-].[P+3]=O>>[Cl:25][C:1]([C:4]1[S:8][C:7]2[CH:9]=[C:10]([CH3:13])[CH:11]=[CH:12][C:6]=2[C:5]=1[S:14]([Cl:26])(=[O:17])=[O:15])=[O:2]

참가 물질

4

반응물 3

HCID 24819Phosphorus pentachlorideHCID 86737645Monosodium 2-carboxy-6-methyl-benzo[b] thiophene-3-sulfonateHCID 178527001HCID 178527001, 화합물

생성물 1

HCID 538745162-Chlorocarbonyl-6-methyl-benzo[b] thiophene-3-sulfonic acid chloride수율 82%

실험 절차

Prepared analogous to Example 1(b) from monosodium 2-carboxy-6-methyl-benzo[b] thiophene-3-sulfonate and phosphorus-(V)-chloride in the presence of phosphorus oxide trichloride with a yield of 82% of theory. The product, which crystallized upon cooling, was used in the next step without further purification.

후처리

  1. customThe product, which crystallized
  2. temperatureupon cooling
  3. customwas used in the next step without further purification

출처 및 근거

ORD 기록
ord-9f28a53b1eba47459e14931769153081
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259336

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