Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
5-Nitro-2-furanmethanediol diacetate → 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H)quinazolinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 5-Nitro-2-furanmethanediol diacetate | HCID 7097 | — |
| 반응물 | 5-Nitrofurfural | HCID 12774 | — |
| 반응물 | Anthranilamide hydrochloride | HCID 23509772 | — |
| 반응물 | 4-({2-[2-(5-Nitrofuran-2-yl)ethenyl]quinazolin-4-yl}amino)phenol | HCID 54073999 | — |
| 반응물 | 2-Methyl-4(3H)-quinazolinone | HCID 135400457 | — |
| 생성물 | 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H)quinazolinone | HCID 136114329 | — |
반응 단계
This example shows preparation of 2-[2-(5-nitro-2-furyl)vinyl]-4-(p-hydroxyanilino)quinazoline, (V). In this preparation, anthranilamide hydrochloride was converted to 2-methyl-4-(3H)quinazolinone (I) and 5-nitrofurfurylidene diacetate to 5-nitro-2-furancarboxaldehyde (II); (I) and (II) were then reacted to obtain 2-[2-(5-nitro-2-furyl)vinyl]-4-(3H) quinazolinone (III); (III) was then chlorinated to obtain 2-[2-(5-nitro-2-furyl)vinyl]-4-chloroquinazoline (IV) which was reacted with p-aminophenol to obtain the desired product, 2-[2-(5-nitro-2-furyl)vinyl]-4-(p-hydroxyanilino)quinazoline (V) and referred to in subsequent examples as the product of Example I. The procedure in this preparation is as follows:
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03973021 |
| 출처 데이터셋 | uspto-grants-1976_08 |
| ORD ID | ord-7949f31e1b6b4dab8fe54c539cf82dd9 |
| 출처 메모 | uspto-grants-1976_08 |