Methyl isothiocyanate → HCID 10198239, 화합물
반응식
[C:1]([C:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH:10]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:11][N:12]=[C:13]=[S:14]>O1CCCC1>[CH3:11][NH:12][C:13]([N:8]1[CH2:7][CH:6]=[C:5]([C:1]([CH3:4])([CH3:3])[CH3:2])[CH2:10][CH2:9]1)=[S:14]참가 물질
4
실험 절차
In 60 ml. of ml.of anhydrous tetrahydrofuran, there is dissolved 12.0 grams of 4-t-butyl-1,2,3,6-tetrahydropyridine. Stirring is initiated and there is added 7.3 grams of methylisothiocyanate in 25 ml. of anhydrous tetrahydrofuran. After stirring the reaction mixture for 18 hours at room temperature, the tetrahydrofuran is evaporated in vacuo at 50°C/20 mmHg. The resulting oil is crystallized from methylene chloride/pentane 1:1 to give N-methyl-4-t-butyl-1,2,3,6-tetrahydro-1-pyridinethiocarboxamide; m.p. 76° to 78°C.
후처리
- stirringAfter stirring the reaction mixture for 18 hours at room temperature
- customthe tetrahydrofuran is evaporated in vacuo at 50°C/20 mmHg
- customThe resulting oil is crystallized from methylene chloride/pentane 1:1
출처 및 근거
- ORD 기록
- ord-1117535de9714f158046d36e0d73596c
- 출처 데이터셋
- uspto-grants-1976_08
- 특허 번호
- US03974283
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