Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ammonia → 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ammonia | HCID 222 | — |
| 반응물 | o-(Trifluoromethyl)benzaldehyde | HCID 123067 | — |
| 반응물 | Ethyl 4-methoxy-3-oxobutanoate | HCID 12645099 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | 2,6-Dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester | HCID 68120665 | 60% |
반응 단계
8.7 g of 2-trifluoromethylbenzaldehyde, 16 g of γ-methoxyacetoacetic acid ethyl ester and 5 ml of aqueous concentrated ammonia in 30 ml of ethanol are heated to the boil overnight, the mixture is cooled and 2,6-dimethoxymethyl-4-(2'-trifluoromethylphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester is obtained in the form of light brown crystals of melting point 133°-134°C, in a yield of 60% of theory.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03974278 |
| 출처 데이터셋 | uspto-grants-1976_08 |
| ORD ID | ord-34ec25078a594fb58e3f762a57550ec8 |
| 출처 메모 | uspto-grants-1976_08 |