Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid

HRID 128352

반응식

HRID 128352 반응식
ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1

참가 물질

3

반응물 2

HCID 6577Chloroacetyl chlorideHCID 3156081H,3H-Thieno[3,4-c]furan-1,3-dione

생성물 1

HCID 255853Thiophene-3,4-dicarboxylic acid

실험 절차

A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.

후처리

  1. temperatureat reflux for 5.5 hours
  2. distillationExcess chloroacetyl chloride is distilled under reduced pressure
  3. additionThe residue is poured into 100 ml
  4. customof water and the resulting crystals are collected
  5. customto yield 16.1 g

출처 및 근거

ORD 기록
ord-cdd40e584b9e4651ba74e24770d441ee
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259476

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