Chloroacetyl chloride → Thiophene-3,4-dicarboxylic acid

반응식

ClCC(Cl)=[O:4].[S:6]1[CH:10]=[C:9]2[C:11]([O:13][C:14](=[O:15])[C:8]2=[CH:7]1)=[O:12]>>[S:6]1[CH:10]=[C:9]([C:11]([OH:4])=[O:12])[C:8]([C:14]([OH:13])=[O:15])=[CH:7]1

참가 물질

반응물 2

HCID 6577Chloroacetyl chloride

HCID 3156081H,3H-Thieno[3,4-c]furan-1,3-dione

생성물 1

HCID 255853Thiophene-3,4-dicarboxylic acid

실험 절차

A 25.5 g. portion of 3,4-thiophenedicarboxylic acid {prepared by the method of Kornfeld and Jones [J. Org. Chem., 19, 1671 (1954)]} is suspended in 50 ml. of chloroacetyl chloride and is heated at reflux for 5.5 hours. Excess chloroacetyl chloride is distilled under reduced pressure. The residue is poured into 100 ml. of water and the resulting crystals are collected to yield 16.1 g. of 3,4-thiophenedicarboxylic anhydride.

후처리

temperatureat reflux for 5.5 hours
distillationExcess chloroacetyl chloride is distilled under reduced pressure
additionThe residue is poured into 100 ml
customof water and the resulting crystals are collected
customto yield 16.1 g

출처 및 근거

ORD 기록: ord-cdd40e584b9e4651ba74e24770d441ee
출처 데이터셋: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04259476

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