Sulfuric Acid → Propanamide, 2-(dimethylamino)-2-methyl-

HRID 1283546노트

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HRID 1283546 반응식
S(=O)(=O)(O)O.[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]#[N:10].[OH-:14].[Ba+2].[OH-]>>[CH3:6][N:7]([CH3:13])[C:8]([CH3:12])([CH3:11])[C:9]([NH2:10])=[O:14]

참가 물질

4

반응물 3

HCID 1118Sulfuric AcidHCID 6093286Barium hydroxideHCID 105108312-(Dimethylamino)-2-methylpropanenitrile

생성물 1

HCID 21409863Propanamide, 2-(dimethylamino)-2-methyl-수율 45%

반응 조건

온도
90 °C

실험 절차

Conc. Sulphuric acid (8 ml.) was added to 2-dimethylamino-2-methyl-propionitrile (2 g.), and was heated to 90°C and allowed to stand for five mins. The reaction mixture was added to ice cold water (100 ml.), barium hydroxide (32 g.) was added to neutralise the acid and the mixture was filtered (hyflo). The filtrate was evaporated under reduced pressure to give a solid residue which was crystallised from light petroleum (80°-100°C) to give 2-dimethylamino-2-methylpropionamide (1 g. 45%) m.p. 109°-111°C.

후처리

  1. additionwas added
  2. filtrationthe mixture was filtered (hyflo)
  3. customThe filtrate was evaporated under reduced pressure
  4. customto give a solid residue which
  5. customwas crystallised from light petroleum (80°-100°C)

출처 및 근거

ORD 기록
ord-0eedefc7dbf448dab6db49e5906563a1
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975443

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