Sulfuric Acid → 1-Ethyl-4-(4-fluorophenyl)benzene

HRID 1283629노트

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HRID 1283629 반응식
C(C1C=CC(C2C=CC=CC=2F)=CC=1)#C.[C:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)#[CH:17].S(=O)(=O)(O)O.[H][H]>>[CH2:16]([C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)[CH3:17]

참가 물질

5

반응물 4

HCID 1118Sulfuric AcidHCID 42040FluretofeneHCID 196905164-Ethynyl-4'-fluoro-1,1'-biphenylHCID 178418361HCID 178418361, 화합물

생성물 1

HCID 214329111-Ethyl-4-(4-fluorophenyl)benzene

실험 절차

The procedure of Example 1 was repeated, except that the 1-ethynyl-4-(2-fluorophenyl)benzene was replaced with 1.5 g of 1-ethynyl-4-(4-fluorophenyl)benzene, the amount of catalyst was reduced to 0.5 g, the sulfuric acid was omitted, initial hydrogen pressure was 48 psig, and the reduction was allowed to proceed overnight. Evaporation of the benzene left a solid which was recrystallized from hexane to give 1-ethyl-4-(4-fluorophenyl)benzene, mp 60°-63°. The following elemental analysis was obtained:

후처리

  1. customEvaporation of the benzene
  2. waitleft a solid which
  3. customwas recrystallized from hexane

출처 및 근거

ORD 기록
ord-393d8f860cee4e81bd68d4bb33aada1b
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03975542

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