Sodium Cyanide → 2-Amino-5-fluorobenzonitrile

HRID 1283710

반응식

HRID 1283710 반응식
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[C:4](I)[CH:3]=1.[C-:10]#[N:11].[Na+]>N1C=CC=CC=1>[C:10]([C:4]1[CH:3]=[C:2]([F:1])[CH:8]=[CH:7][C:5]=1[NH2:6])#[N:11]

참가 물질

4

반응물 2

HCID 8929Sodium CyanideHCID 27782834-Fluoro-2-iodoaniline

생성물 1

HCID 27377042-Amino-5-fluorobenzonitrile

시약·촉매·용매 1

HCID 1049Pyridine용매

실험 절차

Fifteen grams of cuprous cyanide and 14 g. of dry pyridine are heated to a homogeneous melt. After adding 25.0 g. of 4-fluoro-2-iodoaniline, the mixture is heated at about 160°-170° C. for two hours. To the cooled mixture, concentrated sodium cyanide solution is added. The solid material is filtered off and extracted with benzene. The benzene extracts are concentrated and fractionally distilled to give 2-cyano-4-fluoroaniline.

후처리

  1. additionAfter adding 25.0 g
  2. filtrationThe solid material is filtered off
  3. extractionextracted with benzene
  4. concentrationThe benzene extracts are concentrated
  5. distillationfractionally distilled

출처 및 근거

ORD 기록
ord-993385d6121a41b18f4d4c4b7409be99
출처 데이터셋
uspto-grants-1976_08
특허 번호
USRE028939

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