Benzoic Acid → Ethyl benzoate

HRID 1283763노트

반응식

HRID 1283763 반응식
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:10](N(CC)CC)[CH3:11].C(OC(ON=C(C#N)C(N)=O)=O)C.O>O1CCCC1>[C:1]([O:9][CH2:10][CH3:11])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

참가 물질

6

반응물 4

HCID 243Benzoic AcidHCID 962WaterHCID 8471TriethylamineHCID 545656502-Ethoxycarbonyloxyimino-2-cyanoacetic acid amide

생성물 1

HCID 7165Ethyl benzoate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of benzoic acid (1.22 g) and triethylamine (2.8 ml) in dry tetrahydrofuran (20 ml), 2-ethoxycarbonyloxyimino-2-cyanoacetic acid amide (1.85 g) is added at room temperature while stirring, and the resulting mixture is stirred at room temperature for 2 hours. The reaction mixture is admixed with water and extracted with ethyl acetate. The extract is washed with water, an aqueous solution of sodium hydrogencarbonate, 1 N hydrochloric acid and water in order, dried and concentrated to give ethyl benzoate (1.3 g) as an oil.

후처리

  1. stirringthe resulting mixture is stirred at room temperature for 2 hours
  2. extractionextracted with ethyl acetate
  3. washThe extract is washed with water
  4. dry with materialan aqueous solution of sodium hydrogencarbonate, 1 N hydrochloric acid and water in order, dried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-ab81b4ebef49467b954e7d3b6acb4a9a
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03976635

반응 노트

불러오는 중…