Trifluoroacetic acid → 2-Pyrrolidineheptanoic acid

HRID 1283848

반응식

HRID 1283848 반응식
C(OC([N:8]1[CH2:15][CH2:14][CH2:13][C@H:9]1[C:10](O)=O)=O)(C)(C)C.Cl[CH2:17][CH2:18][CH2:19][CH2:20]CCC.F[C:25](F)(F)[C:26]([OH:28])=[O:27]>[Pd]>[NH:8]1[CH2:15][CH2:14][CH2:13][CH:9]1[CH2:10][CH2:17][CH2:18][CH2:19][CH2:20][CH2:25][C:26]([OH:28])=[O:27]

참가 물질

5

반응물 3

HCID 6422Trifluoroacetic acidHCID 123711-ChloroheptaneHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-

생성물 1

HCID 215167142-Pyrrolidineheptanoic acid

시약·촉매·용매 1

HCID 23938Palladium촉매

실험 절차

2-Pyrrolidineheptanoic acid is prepared from N-t-butoxycarbonylproline following steps A and B of Example 4 and step C of the procedure of Example 15. In step C, benzyl ω -chlorohexanoate is substituted for the 1-chloroheptane. The product thus obtained is hydrogenated in the presence of 10% palladium on charcoal and is then treated with trifluoroacetic acid, as in step E of the same procedure.

후처리

  1. customThe product thus obtained

출처 및 근거

ORD 기록
ord-ac43cdb103e74c488b72722a12b4803a
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03976660

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