Imidazole → HCID 20491388, 화합물

HRID 1284074노트

반응식

HRID 1284074 반응식
[C:1]1([C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)(Cl)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1.O>C(#N)C>[C:1]1([C:7]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)([C:18]2[NH:17][CH:21]=[CH:20][N:19]=2)[C:8]#[N:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

참가 물질

5

반응물 3

HCID 795ImidazoleHCID 962WaterHCID 11075152alpha-Chloro-alpha-phenylbenzeneacetonitrile

생성물 1

HCID 20491388HCID 20491388, 화합물

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

5.9 g diphenyl-chloroacetonitrile (prepared from diphenyl-chloroacetamide, Ber. 41, 3593 by heating in phosphorus oxychloride; b.p. 130°C./0.4 mm Hg) are heated with 5 g imidazole in 50 ml acetonitrile at boiling temperature for 18 hours. After treating with 20 ml of water, the mixture is extracted with methylene chloride. The solvent is distilled off after drying in a vacuum. The solid residue is recrystallized from ethyl acetate/petroleum ether. Diphenyl-imidazolyl-acetonitrile i.e. diphenyl-imidazolyl-acetic acid nitrile of m.p. 98°C. is thus obtained.

후처리

  1. customfor 18 hours
  2. extractionthe mixture is extracted with methylene chloride
  3. distillationThe solvent is distilled off
  4. customafter drying in a vacuum
  5. customThe solid residue is recrystallized from ethyl acetate/petroleum ether

출처 및 근거

ORD 기록
ord-631d2e2e78994bb2858a20e0cd87358b
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03978069

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