Acetone → 2-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

HRID 1284275노트

반응식

HRID 1284275 반응식
[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15]Br)([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[C-:21]#[N:22].[K+].CC(C)=O>O>[F:1][C:2]([C:13]1[CH:20]=[CH:19][CH:18]=[CH:17][C:14]=1[CH2:15][C:21]#[N:22])([F:12])[C:3]([F:11])([F:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

참가 물질

5

반응물 3

HCID 180AcetoneHCID 9032Potassium CyanideHCID 203722852-(alpha,alpha,beta,beta-Tetrafluorophenethyl)benzyl bromide

생성물 1

HCID 203722272-(alpha,alpha,beta,beta-Tetrafluorophenethyl)phenylacetonitrile

시약·촉매·용매 1

HCID 962Water용매

실험 절차

2-(α,α,β ,β-Tetrafluorophenethyl)benzyl bromide, 3.5 g. (0.01 mole), and 2.0 g. (0.0308 mole) of potassium cyanide are dissolved in 35 ml. of acetone - 5 ml. of water and the solution is heated to refluxing for about 18 hours. The organic phase is separated, acetone is distilled under reduced pressure, and the residual oil is dissolved in benzene. Evaporation of the washed and dried benzene extract under reduced pressure leaves the product as the residual brown oil.

후처리

  1. temperatureto refluxing for about 18 hours
  2. customThe organic phase is separated
  3. distillationacetone is distilled under reduced pressure
  4. dissolutionthe residual oil is dissolved in benzene
  5. customEvaporation of the
  6. washwashed
  7. extractiondried benzene extract under reduced pressure
  8. customleaves the product as the residual brown oil

출처 및 근거

ORD 기록
ord-ff7cbf6f41f344f09120b13f609ea1f9
출처 데이터셋
uspto-grants-1976_08
특허 번호
US03978127

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