Water → 1-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

HRID 1284566노트

반응식

HRID 1284566 반응식
[CH:1]([C:4]1[CH:11]=[CH:10][C:7]([CH2:8]Cl)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].[C:12]([NH:20][C:21](=[O:29])[NH:22][CH:23]1[CH2:28][CH2:27][NH:26][CH2:25][CH2:24]1)(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C(N(CC)CC)C.O>CN(C)C=O>[C:12]([NH:20][C:21]([NH:22][CH:23]1[CH2:28][CH2:27][N:26]([CH2:8][C:7]2[CH:10]=[CH:11][C:4]([CH:1]([CH3:3])[CH3:2])=[CH:5][CH:6]=2)[CH2:25][CH2:24]1)=[O:29])(=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1

참가 물질

6

반응물 4

HCID 962WaterHCID 8471TriethylamineHCID 749164-Isopropylbenzyl chlorideHCID 126085824-Benzoylureidopiperidine

생성물 1

HCID 129423021-Benzoyl-3-[1-(4-isopropylbenzyl)piperid-4-yl]urea

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

4-Isopropylbenzyl chloride (0.84 g, 0.005 m), 4-benzoylureidopiperidine (1.28 g, 0.005 m) and triethylamine (0.6 g) in dimethylformamide (25 cm3) were stirred at room temperature for 24 hours. Water was added and the precipitated solid filtered off. The solid was suspended in isopropylalcohol and acidified with ethanolic HCl. The title compound was filtered off and dried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate.

후처리

  1. filtrationthe precipitated solid filtered off
  2. filtrationThe title compound was filtered off
  3. dry with materialdried (1.2 g), m.p. 240°-242° C. as the hydrochloride salt, hemihydrate

출처 및 근거

ORD 기록
ord-0cf3f0eb8c4c4f149dfd4dd387a006c3
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04563466

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