Methanol → Methyl 5-chloro-2-nitrobenzoate

HRID 128477

반응식

HRID 128477 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:14]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]

참가 물질

3

반응물 2

HCID 887MethanolHCID 172865-Chloro-2-nitrobenzoic acid

생성물 1

HCID 171018Methyl 5-chloro-2-nitrobenzoate

실험 절차

5-Chloro-2-nitrobenzoic acid (20.1 g,; 0.10 mol), is dissolved in anhydrous methanol (100 ml) and anhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature. The reaction mixture is then poured into water and the aqueous mixture triturated with hexane, the hexane layer decanted, dried (anhd. MgSO4) and the solvent removed under vacuum to afford 11.7 g of methyl 5-chloro-2-nitrobenzoate, mp 50°-51° C.

후처리

  1. customanhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature
  2. additionThe reaction mixture is then poured into water
  3. customthe aqueous mixture triturated with hexane
  4. customthe hexane layer decanted
  5. dry with materialdried (anhd. MgSO4)
  6. customthe solvent removed under vacuum

출처 및 근거

ORD 기록
ord-c210b6f1d1844ee9889f11ccfe0a161c
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259510

연결된 노트

불러오는 중…