Methanol → Methyl 5-chloro-2-nitrobenzoate

반응식

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([OH:9])=[O:8].[CH3:14]O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([O:9][CH3:14])=[O:8]

참가 물질

반응물 2

HCID 887Methanol

HCID 172865-Chloro-2-nitrobenzoic acid

생성물 1

HCID 171018Methyl 5-chloro-2-nitrobenzoate

실험 절차

5-Chloro-2-nitrobenzoic acid (20.1 g,; 0.10 mol), is dissolved in anhydrous methanol (100 ml) and anhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature. The reaction mixture is then poured into water and the aqueous mixture triturated with hexane, the hexane layer decanted, dried (anhd. MgSO4) and the solvent removed under vacuum to afford 11.7 g of methyl 5-chloro-2-nitrobenzoate, mp 50°-51° C.

후처리

customanhydrous hydrogen chloride gas is bubbled into the reaction mixture for 4 hours at room temperature
additionThe reaction mixture is then poured into water
customthe aqueous mixture triturated with hexane
customthe hexane layer decanted
dry with materialdried (anhd. MgSO4)
customthe solvent removed under vacuum

출처 및 근거

ORD 기록: ord-c210b6f1d1844ee9889f11ccfe0a161c
출처 데이터셋: uspto-grants-1981_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US04259510

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