Thionyl Chloride → 2-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

HRID 128495노트

반응식

HRID 128495 반응식
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](O)=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.S(Cl)([Cl:27])=O>CN(C=O)C>[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15]([Cl:27])=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 23469824HCID 23469824, 화합물

생성물 1

HCID 234698232-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

To 17.11 g. (0.05 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid is added 1 ml. of DMF, followed by 50 ml. of thionyl chloride. After evolution of HCl ceases, the thionyl chloride excess is removed in vacuum. The residue is extracted with methylene chloride and the methylene chloride solution washed with ice water, dried, and the solvent removed, leaving 2-[[4-[4-(trifluoromethoxy)phenoxy]-phenoxy]]propanoyl chloride.

후처리

  1. customAfter evolution of HCl ceases, the thionyl chloride excess is removed in vacuum
  2. extractionThe residue is extracted with methylene chloride
  3. washthe methylene chloride solution washed with ice water
  4. customdried
  5. customthe solvent removed

출처 및 근거

ORD 기록
ord-f45e87b23fb34b9daf983d84e798b337
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259532

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