Methylamine → 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide

HRID 128496노트

반응식

HRID 128496 반응식
[F:1][C:2]([F:24])([F:23])[O:3][C:4]1[CH:22]=[CH:21][C:7]([O:8][C:9]2[CH:20]=[CH:19][C:12]([O:13][CH:14]([CH3:18])[C:15](Cl)=[O:16])=[CH:11][CH:10]=2)=[CH:6][CH:5]=1.[CH3:25][NH2:26]>O1CCCC1>[CH3:25][NH:26][C:15](=[O:16])[CH:14]([O:13][C:12]1[CH:19]=[CH:20][C:9]([O:8][C:7]2[CH:21]=[CH:22][C:4]([O:3][C:2]([F:24])([F:23])[F:1])=[CH:5][CH:6]=2)=[CH:10][CH:11]=1)[CH3:18]

참가 물질

4

반응물 2

HCID 6329MethylamineHCID 234698232-[[4-[4-(Trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride

생성물 1

HCID 867368562-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Into a solution of 3.61 g. (0.01 mole) of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoyl chloride in 20 ml. of tetrahydrofuran (THF) is passed a stream of gaseous methylamine. When the reaction is over, the solvent is removed and the residue treated with methylene chloride. The methylene chloride solution is washed with water, dried, and the solvent removed, providing a residue of 2-[[4-[4-(trifluoromethoxy)phenoxy]phenoxy]]propanoic acid, N-methyl amide.

후처리

  1. customis removed
  2. additionthe residue treated with methylene chloride
  3. washThe methylene chloride solution is washed with water
  4. customdried
  5. customthe solvent removed

출처 및 근거

ORD 기록
ord-182e19ef3f4b4ee09dc841751b2838ae
출처 데이터셋
uspto-grants-1981_03
특허 번호
US04259532

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