Methyl 2-methyl-3-nitrobenzoate → 3-Amino-2-methylbenzoic acid methyl ester

HRID 1285

반응식

HRID 1285 반응식
[CH3:1][C:2]1[C:11]([N+:12]([O-])=O)=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]>C(O)(=O)C.[Pd]>[CH3:1][C:2]1[C:11]([NH2:12])=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5]

참가 물질

4

반응물 1

HCID 601165Methyl 2-methyl-3-nitrobenzoate

생성물 1

HCID 38010253-Amino-2-methylbenzoic acid methyl ester수율 101.6%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 176Acetic Acid용매

실험 절차

Methyl 2-methyl-3-nitrobenzoate (10.0 g) is dissolved in acetic acid (50 ml) and thereto 5% Pd-C (1 g) is added to carry out catalytic reduction at room temperature under 1 atm. After 1.5 hours, the catalyst is filtered off. The reaction mixture is concentrated, and thereto is added water, and the mixture is made alkaline with potassium carbonate, followed by extraction with dichloromethane. The solvent is concentrated to give methyl 2-methyl-3-aminobenzoate (8.6 g).

후처리

  1. customat room temperature
  2. filtrationthe catalyst is filtered off
  3. concentrationThe reaction mixture is concentrated
  4. additionis added water
  5. extractionfollowed by extraction with dichloromethane
  6. concentrationThe solvent is concentrated

출처 및 근거

ORD 기록
ord-a382dee7401645edb9da6c1fce7078a0
출처 데이터셋
uspto-grants-1998_03
특허 번호
US05723648

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