p-Toluenesulfonic acid monohydrate → 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate

HRID 1285127노트

반응식

HRID 1285127 반응식
[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1.O.[C:16]1([CH3:26])[CH:21]=[CH:20][C:19]([S:22]([OH:25])(=[O:24])=[O:23])=[CH:18][CH:17]=1>CO>[C:16]1([CH3:26])[CH:17]=[CH:18][C:19]([S:22]([OH:25])(=[O:23])=[O:24])=[CH:20][CH:21]=1.[CH3:1][C:2]1[NH:3][C:4](=[O:14])[CH2:5][S:6][C:7]=1[C:8]1[CH:13]=[CH:12][N:11]=[CH:10][CH:9]=1

참가 물질

4

반응물 2

HCID 521998p-Toluenesulfonic acid monohydrateHCID 30625322H-1,4-Thiazin-3(4H)-one, 5-methyl-6-(4-pyridinyl)-

생성물 1

HCID 202498855-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate수율 62.5%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one (0.88 g) in methanol (30 ml), p-toluenesulfonic acid monohydrate (0.97 g) was gradually added. The reaction mixture was stirred at room temperature for 30 minutes. Methanol was removed under reduced pressure and the residue was recrystallized from ethanol to give 5-methyl-6-(4-pyridinyl)-2H-1,4-thiazin-3(4H)-one p-toluenesulfonate (1 g, yield 62.5%) as yellow fine needles.

후처리

  1. customMethanol was removed under reduced pressure
  2. customthe residue was recrystallized from ethanol

출처 및 근거

ORD 기록
ord-ac70f367dd39476eb09431d1f6e3527f
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565813

반응 노트

불러오는 중…