2-Chloro-5-nitropyridin-4-amine → 1-(4-Fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone

HRID 1285135노트

반응식

HRID 1285135 반응식
NC1C([N+]([O-])=O)=CN=C(Cl)C=1.[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:39])[CH2:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[C:33]([NH2:35])[C:32]([N+:36]([O-])=O)=[CH:31][N:30]=3)[CH2:25][CH2:24]2)=[CH:15][CH:14]=1>C(OCC)(=O)C>[F:12][C:13]1[CH:18]=[CH:17][C:16]([C:19](=[O:39])[CH2:20][CH2:21][CH2:22][N:23]2[CH2:28][CH2:27][N:26]([C:29]3[CH:34]=[C:33]([NH2:35])[C:32]([NH2:36])=[CH:31][N:30]=3)[CH2:25][CH2:24]2)=[CH:15][CH:14]=1

참가 물질

4

반응물 2

HCID 109100582-Chloro-5-nitropyridin-4-amineHCID 202119831-(4-Fluorophenyl)-4-[4-(4-amino-5-nitro-pyridin-2-yl)-1-piperazinyl]-1-butanone

생성물 1

HCID 202119861-(4-Fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

The starting material may be prepared as described in Example 1 starting from 4-amino-2-chloro-5-nitro-pyridine via 1-(4-fluorophenyl)-4-[4-(4-amino-5-nitro-pyridin-2-yl)-1-piperazinyl]-1-butanone to give 1-(4-fluorophenyl)-4-[4-(4,5-diamino-pyridin-2-yl)-1-piperazinyl]-1-butanone, m.p. 166°-169° (from ethyl acetate).

후처리

  1. customThe starting material may be prepared

출처 및 근거

ORD 기록
ord-028ce95a888a4cb8b9988bf483b9ae06
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565816

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