Isopropanol → HCID 20249897, 화합물

HRID 1285163노트

반응식

HRID 1285163 반응식
[N:1]1([C:12](=[O:13])[C:11]2[NH:10][CH:9]=[N:8][C:7]=2[N:5]([CH3:6])[C:3]1=[O:4])[CH3:2].[Na].ClC[C:17]1[N:21]=[C:20]([CH3:22])[O:19][N:18]=1.[CH:23](O)(C)C>>[CH3:22][C:20]1[O:19][N:18]=[C:17]([N:10]2[C:11]3[C:12](=[O:13])[N:1]([CH2:2][CH3:23])[C:3](=[O:4])[N:5]([CH3:6])[C:7]=3[N:8]=[CH:9]2)[N:21]=1

참가 물질

4

반응물 3

HCID 3776IsopropanolHCID 3021573-(Chloromethyl)-5-methyl-1,2,4-oxadiazoleHCID 669736033,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt

생성물 1

HCID 20249897HCID 20249897, 화합물수율 74.2%

실험 절차

20.2 g. of theophylline-sodium, 300 cm3 isopropyl alcohol and 13.2 g. of 3-chloromethyl-5-methyl-1,2,4-oxadiazole are heated under stirring for 10 hours. After processing 20.5 g. (74.2% yield) of 7-(5-methyl-1,2,4-oxadiazol-3-yl)-methyl-theophylline are obtained. M.p.: 134°-135° C.

출처 및 근거

ORD 기록
ord-a3abb1f0d09a48d2a0ed5e645d3ca3d1
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565817

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