Diethylamine → 7-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

HRID 1285164노트

반응식

HRID 1285164 반응식
[Cl:1][CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1.[CH2:22]([NH:24][CH2:25][CH3:26])[CH3:23]>C1(C)C=CC=CC=1>[ClH:1].[CH2:22]([N:24]([CH2:2][C:3]1[O:7][N:6]=[C:5]([CH2:8][N:9]2[C:18]3[C:17](=[O:19])[N:15]([CH3:16])[C:14](=[O:20])[N:13]([CH3:21])[C:12]=3[N:11]=[CH:10]2)[N:4]=1)[CH2:25][CH3:26])[CH3:23]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 202498997-[(5-Chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline

생성물 1

HCID 202499047-[(5-Diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt

시약·촉매·용매 1

HCID 1140Toluene용매

실험 절차

9.0 g. of 7-[(5-chloromethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline, 6 cm3 diethylamine and 50 cm3 toluene are heated on water bath for 8 hours under stirring. The mixture is evaporated at reduced pressure and the residue is washed with water, dissolved in 50 cm3 hot ethanol, treated with activated charcoal and treated with ethanol in hydrochloric acid. 8.3 g of 7-[(5-diethylaminomethyl-1,2,4-oxadiazol-3-yl)-methyl]-theophylline-hydrochloride salt are obtained. M.p.: 207°-210° C.

후처리

  1. customThe mixture is evaporated at reduced pressure
  2. washthe residue is washed with water
  3. dissolutiondissolved in 50 cm3 hot ethanol
  4. additiontreated with activated charcoal
  5. additiontreated with ethanol in hydrochloric acid

출처 및 근거

ORD 기록
ord-78a7ee4f793449e9bdd6877a0a10ff67
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565817

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