3-(2-Chloroethyl)-5-methyl-1,2,4-oxadiazole → 7-[2-(5-Methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline

HRID 1285173

반응식

HRID 1285173 반응식
Cl[CH2:2][CH2:3][C:4]1[N:8]=[C:7]([CH3:9])[O:6][N:5]=1.[Na].[N:11]1([C:22](=[O:23])[C:21]2[NH:20][CH:19]=[N:18][C:17]=2[N:15]([CH3:16])[C:13]1=[O:14])[CH3:12]>C(O)(C)C>[CH3:9][C:7]1[O:6][N:5]=[C:4]([CH2:3][CH2:2][N:20]2[C:21]3[C:22](=[O:23])[N:11]([CH3:12])[C:13](=[O:14])[N:15]([CH3:16])[C:17]=3[N:18]=[CH:19]2)[N:8]=1

참가 물질

4

반응물 2

HCID 125514573-(2-Chloroethyl)-5-methyl-1,2,4-oxadiazoleHCID 669736033,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, sodium salt

생성물 1

HCID 202499187-[2-(5-Methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline수율 91%

시약·촉매·용매 1

HCID 3776Isopropanol용매

실험 절차

2.92 g. of 3-(2-chloroethyl)-5-methyl-1,2,4-oxadiazole, 50 cm3 isopropylalcohol and 4.0 g. of theophylline sodium are heated for 8 hours. 5.3 g. (91% yield) 7-[2-(5-methyl-1,2,4-oxadiazol-3-yl)-ethan-1-yl]-theophylline are obtained, m.p.: 113°-114° C. (water).

출처 및 근거

ORD 기록
ord-f721d139db7b4929b3036d63a38560bb
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565817

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