Sodium Iodide → 7H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-

HRID 1285175

반응식

HRID 1285175 반응식
Cl[CH2:2][CH2:3][CH2:4][N:5]1[C:14]2[C:13](=[O:15])[N:11]([CH3:12])[C:10](=[O:16])[N:9]([CH3:17])[C:8]=2[N:7]=[CH:6]1.[C-:18]#[N:19].[Na+].[I-].[Na+]>CN(C)C=O>[N:11]1([C:13](=[O:15])[C:14]2[N:5]([CH2:4][CH2:3][CH2:2][C:18]#[N:19])[CH:6]=[N:7][C:8]=2[N:9]([CH3:17])[C:10]1=[O:16])[CH3:12]

참가 물질

5

반응물 3

HCID 5238Sodium IodideHCID 8929Sodium CyanideHCID 760117-(3-Chloropropyl)-3,7-dihydro-1,3-dimethyl-1H-purine-2,6-dione

생성물 1

HCID 6102347H-Purine-7-butanenitrile, 1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-수율 88%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

57.9 g. of 7-(3-chloro-propan-1-yl)-theophylline, 12.29 g. of sodium cyanide, 2.0 g. of sodium iodide and 400 cm3 of dimethylformamide are stirred at 90° C. for 3 hours. 49.1 g. (88% yield) of γ-(theophylline-7-yl)-butyronitrile are obtained. M.p.: 146°-150° C.

출처 및 근거

ORD 기록
ord-5775af0a11f74eaeac2e66a0d237763a
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565817

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