Thionyl Chloride → 2,5-Dichloro-3,4,6-trifluorobenzoyl chloride

HRID 128524노트

반응식

HRID 128524 반응식
S(Cl)([Cl:3])=O.[Cl:5][C:6]1[C:14]([F:15])=[C:13]([F:16])[C:12]([Cl:17])=[C:11]([F:18])[C:7]=1[C:8](O)=[O:9]>CN(C)C=O>[Cl:5][C:6]1[C:14]([F:15])=[C:13]([F:16])[C:12]([Cl:17])=[C:11]([F:18])[C:7]=1[C:8]([Cl:3])=[O:9]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 190738192,5-Dichloro-3,4,6-trifluorobenzoic acid

생성물 1

HCID 193743882,5-Dichloro-3,4,6-trifluorobenzoyl chloride

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

160 ml of thionyl chloride are initially introduced into the reaction vessel at room temperature. 36.8 g (0.15 mol) of 2,5-dichloro-3,4,6-trifluorobenzoic acid are added in portions, while stirring. After addition of 0.5 ml of dimethylformamide, the mixture is slowly heated to 80°-90° C. and is stirred at this temperature for 5 hours. It is then concentrated and the residue is distilled under a high vacuum.

후처리

  1. temperaturethe mixture is slowly heated to 80°-90° C.
  2. stirringis stirred at this temperature for 5 hours
  3. concentrationIt is then concentrated
  4. distillationthe residue is distilled under a high vacuum

출처 및 근거

ORD 기록
ord-76f4d5caadeb4de984d439daec32b82c
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464796

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