Ethyl 7-hydroxy-4-oxo-8-propyl-4H-chromene-2-carboxylate → 2-Carboethoxy-7-[5-(2-n-propylphenoxy)pentoxy]-8-n-propylchromone

HRID 1285258노트

반응식

HRID 1285258 반응식
[OH:1][C:2]1[C:11]([CH2:12][CH2:13][CH3:14])=[C:10]2[C:5]([C:6](=[O:20])[CH:7]=[C:8]([C:15]([O:17][CH2:18][CH3:19])=[O:16])[O:9]2)=[CH:4][CH:3]=1.[CH2:21]([C:24]1[CH:36]=[CH:35][CH:34]=[CH:33][C:25]=1[O:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]Br)[CH2:22][CH3:23]>>[C:15]([C:8]1[O:9][C:10]2[C:5]([C:6](=[O:20])[CH:7]=1)=[CH:4][CH:3]=[C:2]([O:1][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][O:26][C:25]1[CH:33]=[CH:34][CH:35]=[CH:36][C:24]=1[CH2:21][CH2:22][CH3:23])[C:11]=2[CH2:12][CH2:13][CH3:14])([O:17][CH2:18][CH3:19])=[O:16]

참가 물질

3

반응물 2

HCID 4196515Ethyl 7-hydroxy-4-oxo-8-propyl-4H-chromene-2-carboxylateHCID 137732081-(5-Bromopentoxy)-2-propylbenzene

생성물 1

HCID 135378642-Carboethoxy-7-[5-(2-n-propylphenoxy)pentoxy]-8-n-propylchromone수율 80%

실험 절차

Using essentially the method of Example 2, 2.76 g (10 mmole) of ethyl 7-hydroxy-8-n-propylchromone-2-carboxylate and 8.18 g (11 mmole) of 5-(2-n-propylphenoxy)-1-bromopentane, gave 3.84 g (80%) of the title compound, mp 73°-75°. Calc: C, 72.48; H, 7.55; Found: C, 72.24; H, 7.63.

출처 및 근거

ORD 기록
ord-ca1faadb2fbb456d9e8118d014964647
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04565882

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