1-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1) → Doxepin

HRID 1285337

반응식

HRID 1285337 반응식
[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3].Cl.C(=O)(O)[O-].[Na+]>O>[CH3:1][N:2]([CH2:4][CH2:5][CH:6]=[C:7]1[C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[O:15][CH2:14][C:13]2[CH:12]=[CH:11][CH:10]=[CH:9][C:8]1=2)[CH3:3]

참가 물질

4

반응물 2

HCID 146751-Propanamine, 3-(dibenz[b,e]oxepin-11(6H)-ylidene)-N,N-dimethyl-, hydrochloride (1:1)HCID 516892Sodium Bicarbonate

생성물 1

HCID 3158Doxepin

시약·촉매·용매 1

HCID 962Water용매2회

실험 절차

Doxepin hydrochloride (10 g., 0.032 mol) was dissolved in 50 ml. H2O. Sodium bicarbonate (3.2 g., 0.038 mol) suspended in 25 ml. of H2O was added with stirring, and the mixture stirred for 20 minutes and then extracted 3×50 ml. ether. The ether extracts were combined, dried (Na2SO4) and evaporated in vacuo to yield doxepin as an oil (8.33 g.).

후처리

  1. stirringthe mixture stirred for 20 minutes
  2. extractionextracted 3×50 ml
  3. dry with materialdried (Na2SO4)
  4. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-c91b9163108f4b619c0fca596a0e1400
출처 데이터셋
uspto-grants-1986_01
특허 번호
US04567179

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