Thionyl Chloride → 2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride

HRID 128585노트

반응식

HRID 128585 반응식
[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5](O)=[O:6].S(Cl)([Cl:24])=O>C1COCC1>[CH3:1][O:2][C:3]1[CH:11]=[C:10]([O:12][CH:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:21])[CH3:20])[CH2:15][CH2:14]2)[CH:9]=[CH:8][C:4]=1[C:5]([Cl:24])=[O:6]

참가 물질

4

반응물 2

HCID 24386Thionyl ChlorideHCID 189141452-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid

생성물 1

HCID 189141812-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

2-Methoxy-4-(1-acetyl-4-piperidyloxy)benzoic acid (0.546 g, 1.86 mmol) in THF (10 ml) was stirred under nitrogen and treated with thionyl chloride (0.27 ml, 0.44 g, 3.7 mmol). The mixture was stirred at ambient temperature for 18 hours, then concentrated in vacuo to give 2-methoxy-4-(1-acetyl-4-piperidyloxy)benzoyl chloride.

후처리

  1. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-8b1f1758ce4e492db966f2df6ed7b336
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464788

반응 노트

불러오는 중…