Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Thiomorpholine → Methyl-5-thiomorpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Thiomorpholine | HCID 67164 | — |
| 반응물 | 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 25013543 | — |
| 생성물 | Methyl-5-thiomorpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide | HCID 58972884 | — |
반응 단계
Heating a mixture of 5-chloro-1-methyl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (Example 5, 60 mg; 0.20 mmol) and thiomorpholine (0.20 mL; 2.0 mmol) to 250° C. under microwave irradiation according to the procedure described in Example 14 provided after purification by reverse phase HPLC, 1-methyl-5-thiomorpholin-4-yl-1H-pyrazole-4-carboxylic acid adamantan-2-ylamide (15 mg, 21%) as light brown powder. ES-HRMS m/e calcd for C19H29N4OS4 (M+H+) 361.2057, found 361.2053.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07728029B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-ab8f06c15335493f9ba9782a67a1932b |
| 출처 메모 | uspto-grants-2010_06 |