3-(Pyridin-3-yl)propanoic acid → HCID 45261551, 화합물

HRID 128648

반응식

HRID 128648 반응식
[Cl:1][C:2]1[CH:20]=[CH:19][C:5]2[O:6][C:7]3[CH:18]=[CH:17][CH:16]=[CH:15][C:8]=3[CH2:9][N:10]([C:11]([NH:13][NH2:14])=[O:12])[C:4]=2[CH:3]=1.[N:21]1[CH:26]=[CH:25][CH:24]=[C:23]([CH2:27][CH2:28][C:29](O)=[O:30])[CH:22]=1>C(O)(=O)C>[ClH:1].[O:30]=[C:29]([NH:14][NH:13][C:11]([N:10]1[CH2:9][C:8]2[CH:15]=[CH:16][CH:17]=[CH:18][C:7]=2[O:6][C:5]2[CH:19]=[CH:20][C:2]([Cl:1])=[CH:3][C:4]1=2)=[O:12])[CH2:28][CH2:27][C:23]1[CH:22]=[N:21][CH:26]=[CH:25][CH:24]=1

참가 물질

4

반응물 2

HCID 2596243-(Pyridin-3-yl)propanoic acidHCID 135604618-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide

생성물 1

HCID 45261551HCID 45261551, 화합물

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

The experiment described above in Example 7 was repeated on a five mmol scale with 8-chlorodibenz[b,f][1,41oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, and 3-(3-pyridyl)propionic acid. The yield of the reaction product was 0.75 g (34%). The free base was dissolved in 5 mL of acetic acid (HOAc) and filtered. To the filtrate was added 5 mL of 6N HCl dioxane. The hydrochloride salt was precipitated from the reaction by the addition of Et2O. The resultant solid product was collected by filtration and dried in an Abderhalden drying pistol. Analysis calculated for C22H20N4O3Cl2 : C, 57.53; H, 4.39; N, 12.20; Cl, 15.44. Found: C, 57.35; H, 4.45; N, 12.08; Cl, 15.58.

후처리

  1. customprepared
  2. filtrationfiltered
  3. additionTo the filtrate was added 5 mL of 6N HCl dioxane
  4. customThe hydrochloride salt was precipitated from the reaction by the addition of Et2O
  5. filtrationThe resultant solid product was collected by filtration
  6. customdried in an Abderhalden
  7. customdrying pistol

출처 및 근거

ORD 기록
ord-f085158a85954a30a31044d6807651fc
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464830

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