8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide → 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3E-butenyl]hydrazide

참여 물질

역할	이름	HCID	투입량
반응물	8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide	HCID 13560461	—
반응물	4-(3-Thienyl)-3-butenoic acid	HCID 53832482	—
생성물	8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3E-butenyl]hydrazide	HCID 86748369	—
생성물	8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3Z-butenyl]hydrazide	HCID 86748370	—

반응 단계

8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3E-butenyl]hydrazide (trans) (30) and 8-chlorodibenz[b,f][1,4 ]oxazepine-10(11H)-carboxylic acid, 2-[1-oxo-4-(3-thienyl)-3Z-butenyl]hydrazide (cis) (31) were prepared in the manner described in Example 7 on a 5.2 mmol scale from 4-(3-thienyl)-3-butenoic acid (29), prepared as described above in Example 29, and 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, hydrazide (1), prepared as described above in Example 1, to yield 33% trans and 14% cis products after separation by column chromatography.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US05464830
출처 데이터셋	uspto-grants-1995_11
ORD ID	ord-c45bc94649a046478db5ef1f93050175
출처 메모	uspto-grants-1995_11