Ethanone, 1-(2,4,6-trimethylphenyl)- → 2-Bromo-1-mesitylethanone

HRID 128685

반응식

HRID 128685 반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[C:10](=[O:12])[CH3:11].[Br:13]Br>C(O)(=O)C>[Br:13][CH2:11][C:10]([C:3]1[C:4]([CH3:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1])=[O:12]

참가 물질

4

반응물 2

HCID 15461Ethanone, 1-(2,4,6-trimethylphenyl)-HCID 24408Bromine

생성물 1

HCID 2194802-Bromo-1-mesitylethanone

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate.

후처리

  1. temperaturewhile maintaining the reaction medium at a temperature below 10° C
  2. additionWhen the addition
  3. customto return to room temperature
  4. customleave at this temperature for 2 hours
  5. extractionextract the aqueous phase with ethyl ether
  6. washWash the organic extracts with saturated aqueous sodium bicarbonate solution
  7. dry with materialwith salt water, and dry over anhydrous magnesium sulphate

출처 및 근거

ORD 기록
ord-1d73ba4322e04fd2a72493a5e232af53
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464847

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