Ethanone, 1-(2,4,6-trimethylphenyl)- → 2-Bromo-1-mesitylethanone
반응식
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[C:4]([CH3:9])[C:3]=1[C:10](=[O:12])[CH3:11].[Br:13]Br>C(O)(=O)C>[Br:13][CH2:11][C:10]([C:3]1[C:4]([CH3:9])=[CH:5][C:6]([CH3:8])=[CH:7][C:2]=1[CH3:1])=[O:12]참가 물질
4
실험 절차
Dissolve 0.3 mol of 1-(2,4,6-trimethylphenyl)-1-ethanone in 200 ml of glacial acetic acid, and add 31.8 g of bromine dropwise while maintaining the reaction medium at a temperature below 10° C. When the addition is complete, allow the reaction medium to return to room temperature and leave at this temperature for 2 hours. Then pour the reaction medium into 500 ml of ice-cold water and extract the aqueous phase with ethyl ether. Wash the organic extracts with saturated aqueous sodium bicarbonate solution and then with salt water, and dry over anhydrous magnesium sulphate.
후처리
- temperaturewhile maintaining the reaction medium at a temperature below 10° C
- additionWhen the addition
- customto return to room temperature
- customleave at this temperature for 2 hours
- extractionextract the aqueous phase with ethyl ether
- washWash the organic extracts with saturated aqueous sodium bicarbonate solution
- dry with materialwith salt water, and dry over anhydrous magnesium sulphate
출처 및 근거
- ORD 기록
- ord-1d73ba4322e04fd2a72493a5e232af53
- 출처 데이터셋
- uspto-grants-1995_11
- 특허 번호
- US05464847
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