2-(Chloromethyl)-4-isopropyl-6-methoxybenzo[D]isothiazol-3(2H)-one 1,1-dioxide → 2-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-6-methoxysaccharin

HRID 128704

반응식

HRID 128704 반응식
Cl[CH2:2][N:3]1[C:13](=[O:14])[C:12]2[C:7](=[CH:8][C:9]([O:18][CH3:19])=[CH:10][C:11]=2[CH:15]([CH3:17])[CH3:16])[S:4]1(=[O:6])=[O:5].[Na].[C:21]1([N:27]2[C:31]([SH:32])=[N:30][N:29]=[N:28]2)[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1>CN(C)C=O>[C:21]1([N:27]2[C:31]([S:32][CH2:2][N:3]3[C:13](=[O:14])[C:12]4[C:7](=[CH:8][C:9]([O:18][CH3:19])=[CH:10][C:11]=4[CH:15]([CH3:17])[CH3:16])[S:4]3(=[O:6])=[O:5])=[N:30][N:29]=[N:28]2)[CH:22]=[CH:23][CH:24]=[CH:25][CH:26]=1

참가 물질

4

반응물 2

HCID 99951732-(Chloromethyl)-4-isopropyl-6-methoxybenzo[D]isothiazol-3(2H)-one 1,1-dioxideHCID 178527989HCID 178527989, 화합물

생성물 1

HCID 98897272-(1-Phenyltetrazol-5-yl)thiomethyl-4-isopropyl-6-methoxysaccharin수율 83%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2-chloromethyl-4-isopropyl-6-methoxysaccharin (0.25 g) and 1-phenyltetrazole-5-thiol sodium salt (0.173 g) in dimethylformamide (10 mL) was heated at 60°-80° C. for 8 hours, then poured into ice-water containing saturated aqueous sodium bicarbonate. The resulting mixture was extracted with ether. The ether extract was washed with water and saturated aqueous sodium chloride, passed through silica gel and is stripped of ether affording 2-(1-phenyltetrazol-5-yl)thiomethyl-4-isopropyl-6-methoxysaccharin as a foam (0.3 g, 83% yield).

후처리

  1. temperaturewas heated at 60°-80° C. for 8 hours
  2. extractionThe resulting mixture was extracted with ether
  3. extractionThe ether extract
  4. washwas washed with water and saturated aqueous sodium chloride

출처 및 근거

ORD 기록
ord-ab3ebf0914af4952a968c7ec84693c55
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464852

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