Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → Theofibrate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Etofylline | HCID 1892 | — |
| 반응물 | Clofibric Acid | HCID 2797 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 촉매 | p-Toluenesulfonic acid | HCID 6101 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | Theofibrate | HCID 41109 | 55.1% |
반응 단계
107.3 g (0.5 mol) 2-(p-chlorophenoxy) isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene and heated for 15 hours in a water separator after addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), waterwashed and evaporated in a rotary evaporator. The residue was crystallized from isopropanol, yielding 58.0 g (55% yield) 1-(7-theophyllinyl)-2-ethyl [2-(p-chlorophenoxy)-isobutyrate] with a melting point 131°-132°C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US03984413 |
| 출처 데이터셋 | uspto-grants-1976_10 |
| ORD ID | ord-5842ddc15eb14601bf44c55cda34357f |
| 출처 메모 | uspto-grants-1976_10 |