Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Diisopropyl Ether → N-(1,5-dimethylpyrazol-3-yl)-2,6 dimethyl benzamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Diisopropyl Ether | HCID 7914 | — |
| 반응물 | 2,6-Dimethylbenzoyl chloride | HCID 89096 | — |
| 반응물 | Sodium Bicarbonate | HCID 516892 | — |
| 반응물 | 1,5-dimethyl-1H-pyrazol-3-amine | HCID 7017747 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | N-(1,5-dimethylpyrazol-3-yl)-2,6 dimethyl benzamide | HCID 11776550 | 38.2% |
반응 단계
To a cooled (0°-5° C.) solution of 3-amino-1,5-dimethyl pyrazole (95%, 32.7 g, 0.28M) in anhydrous CH2Cl2 (200 ml) was added a CH2Cl2 (100 ml) solution of the 2,6 dimethyl benzoyl chloride (23.6 g, 0.14M). The reaction mixture was allowed to room temperature for 18 hours and then CH2Cl2 was concentrated to give an oily mixture which was diluted in AcOEt. This suspension was then treated with saturated NaHCO3. After usual work-up, the crude material was cristallized with diisopropyloxide to give 13 g of the desired amide (38% : yield based on the 2,6-dimethyl benzoyl chloride).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05464860 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-f98ffc91eb5e435fac5c17e51ecfdfc5 |
| 출처 메모 | uspto-grants-1995_11 |