HCID 12235831, 화합물 → 2-[2-(Piperidin-1-yl)ethyl]aniline
반응식
[CH:1]1[C:6]2[CH2:7][CH2:8][N:9]3[CH:15]=[CH:14][CH:13]=[CH:12][C:10]3=[N:11][C:5]=2[CH:4]=[CH:3][CH:2]=1.[H][H]>[Pt]=O.CO>[NH2:11][C:5]1[CH:4]=[CH:3][CH:2]=[CH:1][C:6]=1[CH2:7][CH2:8][N:9]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:10]1참가 물질
5
실험 절차
Platinum oxide catalyst (1.0 g) is added to a solution of 11,12-dihydropyrido[2,1-b][1,3]benzodiazepine (20.0 g) in methanol (550 ml). Hydrogen gas (about 50 psig) is added and hydrogen uptake is completed in about 1 and 2 hours. The catalyst is filtered off, and the filtrate is concentrated to yield 22.0 g of material that crystallizes spontaneously, melting point 36°-38° C. Recrystallization from 150 ml of pentane yields 16.0 g of the title compound, melting point 39°-41° C.
후처리
- customis completed in about 1 and 2 hours
- filtrationThe catalyst is filtered off
- concentrationthe filtrate is concentrated
출처 및 근거
- ORD 기록
- ord-668e8065c14d4d5d8e589d3912ecbf00
- 출처 데이터셋
- uspto-grants-1976_10
- 특허 번호
- US03984421
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