2,3-Dichlorobenzaldehyde → 5-[(2,3-Dichlorophenyl)methylene]-2-thioxo-4-thiazolidinone

HRID 128727

반응식

HRID 128727 반응식
[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[S:11]1[CH2:17][C:15](=[O:16])[NH:14][C:12]1=[S:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[Cl:1][C:2]1[C:9]([Cl:10])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[C:17]1[S:11][C:12](=[S:13])[NH:14][C:15]1=[O:16]

참가 물질

5

반응물 3

HCID 357452,3-DichlorobenzaldehydeHCID 517045Sodium AcetateHCID 1201546Rhodanine

생성물 1

HCID 28543725-[(2,3-Dichlorophenyl)methylene]-2-thioxo-4-thiazolidinone수율 40%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

A mixture of 2,3-dichlorobenzaldehyde (4.6 g, mmoles), rhodanine (3.5 g, 25 mmoles), sodium acetate (7.5 g, 91 mmoles), and acetic acid (40 ml) is stirred under an inert atmosphere and heated to reflux. After 2.5 hours the mixture is stirred into ice-water (250 ml) and the precipitate is filtered off, rinsed three times with water and dried. Recrystallization from methanol gave the pure product (2.9 g), mp 203°-204° C.

후처리

  1. temperatureheated to reflux
  2. filtrationthe precipitate is filtered off
  3. washrinsed three times with water
  4. customdried
  5. customRecrystallization from methanol

출처 및 근거

ORD 기록
ord-029bb7e8f5a3430fb8eff75b0d44cb04
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464856

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