4-Hydroxy-3,5-bis(isopropyl)benzaldehyde → 5-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone

HRID 128733

반응식

HRID 128733 반응식
[OH:1][C:2]1[C:9]([CH:10]([CH3:12])[CH3:11])=[CH:8][C:5]([CH:6]=O)=[CH:4][C:3]=1[CH:13]([CH3:15])[CH3:14].[NH:16]1[CH2:22][C:20](=[O:21])[NH:19][C:17]1=[S:18].C([O-])(=O)C.[Na+]>C(O)(=O)C>[OH:1][C:2]1[C:9]([CH:10]([CH3:12])[CH3:11])=[CH:8][C:5]([CH:6]=[C:22]2[NH:16][C:17](=[S:18])[NH:19][C:20]2=[O:21])=[CH:4][C:3]=1[CH:13]([CH3:15])[CH3:14]

참가 물질

5

반응물 3

HCID 827124-Hydroxy-3,5-bis(isopropyl)benzaldehydeHCID 517045Sodium AcetateHCID 12740302-Thiohydantoin

생성물 1

HCID 539462155-[[4-Hydroxy-3,5-bis(1-methylethyl)phenyl]methylene]-2-thioxo-4-imidazolidinone수율 32.9%

시약·촉매·용매 1

HCID 176Acetic Acid용매

실험 절차

Prepared according to the procedure described in Example 1 using 4-hydroxy-3,5-bis(1-methylethyl)benzaldehyde (3.0 g, 15 mmoles), 2-thiohydantoin (1.6 g, 14 mmoles), sodium acetate (4.2 g, 51 mmoles), and acetic acid (35 ml), filtered off, dried, and recrystallized from acetonitrile to afford the pure product (1.4 g), mp 225°-230° C.

후처리

  1. customPrepared
  2. filtrationfiltered off
  3. customdried
  4. customrecrystallized from acetonitrile

출처 및 근거

ORD 기록
ord-94182eba54ee4fcc8316740632dfd6a6
출처 데이터셋
uspto-grants-1995_11
특허 번호
US05464856

연결된 노트

불러오는 중…