Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetic Anhydride → 5-[(2-Methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetic Anhydride | HCID 7918 | — |
| 반응물 | 2-Methoxybenzaldehyde | HCID 8658 | — |
| 반응물 | Sodium Acetate | HCID 517045 | — |
| 반응물 | 2-Thiohydantoin | HCID 1274030 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 5-[(2-Methoxyphenyl)methylene]-2-thioxo-4-imidazolidinone | HCID 3004672 | 85.4% |
반응 단계
A mixture of 2-methoxybenzaldehyde (2.5 g, 18 mmoles), 2-thiohydantoin (2.0 g, 17 mmoles), sodium acetate (4.0 g, 49 mmoles), acetic anhydride (μml), and acetic acid (15 ml) is stirred under an inert atmosphere and heated to reflux. After 1 hour the mixture is stirred into water (300 ml), and the precipitate is filtered off, rinsed with water three times and dried. The product is triturated in boiling methanol, filtered off, and dried to afford the pure product (3.4 g), mp 234°-235° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05464856 |
| 출처 데이터셋 | uspto-grants-1995_11 |
| ORD ID | ord-c994d1b65e984355a391b6af2b305182 |
| 출처 메모 | uspto-grants-1995_11 |