Sodium Methoxide → 10-methyl-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione
반응식
[CH3:1][NH:2][C:3]1[C:4](=[CH:15][CH:16]=[CH:17][CH:18]=1)[C:5]([N:7]1[CH2:14][CH2:13][CH2:12][C@H:8]1[C:9](O)=[O:10])=[O:6].C[O-].[Na+]>C(O)C>[CH3:1][N:2]1[C:3]2[CH:18]=[CH:17][CH:16]=[CH:15][C:4]=2[C:5](=[O:6])[N:7]2[CH2:14][CH2:13][CH2:12][CH:8]2[C:9]1=[O:10]참가 물질
4
실험 절차
Ten grams of the ethyl ester of 1-(N-methylanthraniloyl)proline is dissolved in 100 ml. of ethanol and 3.0 g. of sodium methylate is added. The reaction mixture is heated at reflux temperature for 8 hours and concentrated to remove the solvent. The residue is shaken with benzene and the benzene solution is washed twice with water and concentrated. The residue is purified by recrystallization from ethyl acetate.
후처리
- temperatureThe reaction mixture is heated
- temperatureat reflux temperature for 8 hours
- concentrationconcentrated
- customto remove the solvent
- washthe benzene solution is washed twice with water
- concentrationconcentrated
- customThe residue is purified by recrystallization from ethyl acetate
출처 및 근거
- ORD 기록
- ord-f252478c956e4403bd9e7b6a8f32e2b3
- 출처 데이터셋
- uspto-grants-1976_10
- 특허 번호
- US03985732
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