Benzhydryl 2-chloroethyl ether → 1'-(2-Benzhydryloxyethyl)-1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]-3-one

HRID 1287920노트

반응식

HRID 1287920 반응식
[NH:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[O:7]2)[CH2:3][CH2:2]1.[CH:16]([O:29][CH2:30][CH2:31]Cl)([C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>>[CH:16]([O:29][CH2:30][CH2:31][N:1]1[CH2:6][CH2:5][C:4]2([C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[O:7]2)[CH2:3][CH2:2]1)([C:23]1[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=1)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

3

반응물 2

HCID 141724Benzhydryl 2-chloroethyl etherHCID 98342553H-spiro(isobenzofuran-1,4'-piperidin)-3-one

생성물 1

HCID 215068271'-(2-Benzhydryloxyethyl)-1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]-3-one

실험 절차

Reaction of 1,3-dihydrospiro[isobenzofuran1,4'-piperidine]-3-one and 2-benzhydryloxy-1-chloroethane by the method described in Example 5d provides 1'-(2-benzhydryloxyethyl)-1,3-dihydrospiro[isobenzofuran-1,4'-piperidine]- 3-one as colorless crystals, m.p. 99°-100°.

출처 및 근거

ORD 기록
ord-7a52f55ab06b419aa57e011bdd1fcf9e
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03985889

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