Benzene → 1-Ethynyl-4-methoxynaphthalene

HRID 1287929노트

반응식

HRID 1287929 반응식
C1([Li])C=CC=CC=1.Br[CH:9]=[CH:10][C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([O:21][CH3:22])=[CH:13][CH:12]=1.C1C=CC=CC=1>O>[C:10]([C:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[C:14]([O:21][CH3:22])=[CH:13][CH:12]=1)#[CH:9]

참가 물질

5

반응물 3

HCID 241BenzeneHCID 544133521-(2-Bromoethenyl)-4-methoxynaphthaleneHCID 178506676HCID 178506676, 화합물

생성물 1

HCID 123269971-Ethynyl-4-methoxynaphthalene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Phenyllithium (164 ml. of 2.1 M, 0.345 mol.) was added dropwise to a solution of 35.9 g. (0.138 mol.) of 1-(2-bromoethenyl)-4methoxynaphthalene in 120 ml. of refluxing dry benzene under a nitrogen atmosphere. After addition the reaction mixture was refluxed for 30 minutes, then ice and water were slowly added. The mixture was shaken, the layers separated and the organic phase was washed with water and saturated sodium chloride solution, dried (MgSO4) and evaporated to give 1-ethynyl-4-methoxynaphthalene.

후처리

  1. additionAfter addition the reaction mixture
  2. temperaturewas refluxed for 30 minutes
  3. customthe layers separated
  4. washthe organic phase was washed with water and saturated sodium chloride solution
  5. dry with materialdried (MgSO4)
  6. customevaporated

출처 및 근거

ORD 기록
ord-b5415cf9ad40412ea1b94a460feec1d8
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03985896

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