Dimethylformamide → 4-(2-Methoxyethenyl) benzaldehyde

HRID 128795

반응식

Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]=[CH:9][O:10][CH3:11])=[CH:4][CH:3]=1.CN(C)[CH:14]=[O:15]>>[CH3:11][O:10][CH:9]=[CH:8][C:5]1[CH:6]=[CH:7][C:2]([CH:14]=[O:15])=[CH:3][CH:4]=1

참가 물질

반응물 2

HCID 6228Dimethylformamide

HCID 534071961-Bromo-4-(2-methoxyvinyl)benzene

생성물 1

HCID 540896124-(2-Methoxyethenyl) benzaldehyde

실험 절차

By the method of example 28, 1-bromo-4-(2-methoxyethenyl)benzene is prepared, lithiated, and reacted with dimethylformamide to provide 4-(2-methoxyethenyl) benzaldehyde as a yellow oil after chromatography. This material is converted to 1-(2-phenylethenyl)-4-(2-methoxyethenyl)benzene by Wittig reaction with benzyl triphenylphosphonium chloride, using the conditions described in example 1 (A). The material is obtained as a mixture of all four possible (E) and (Z) stereoisomers.

출처 및 근거

ORD 기록: ord-d13b8a86eb3742028c827cbf275607ac
출처 데이터셋: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05464865

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