4-(2-Chloro-2-cyanoethyl)benzoic acid → 4-(2-Cyanoethyl)benzoic acid

HRID 1287957노트

반응식

HRID 1287957 반응식
Cl[CH:2]([C:13]#[N:14])[CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1>[Zn].C(O)(=O)C>[C:13]([CH2:2][CH2:3][C:4]1[CH:12]=[CH:11][C:7]([C:8]([OH:10])=[O:9])=[CH:6][CH:5]=1)#[N:14]

참가 물질

4

반응물 1

HCID 508886404-(2-Chloro-2-cyanoethyl)benzoic acid

생성물 1

HCID 198791964-(2-Cyanoethyl)benzoic acid

시약·촉매·용매 2

HCID 23994Zinc촉매HCID 176Acetic Acid용매

실험 절차

100 parts of zinc powder are gradually added to a solution of 209.5 parts of 4-(2-chloro-2-cyanoethyl) benzoic acid in 500 parts of glacial acetic acid. The temperature rises quickly up to reflux and is maintained for approximately 1 hour. The solution is filtered when hot so a to eliminate the insoluble matter, then the filtrate is diluted with 1000 parts of water and the precipitate formed is isolated. Thus 122 parts of 4-(2-cyanoethyl) benzoic acid are obtained. M.P.: 182° C.

후처리

  1. temperatureto reflux
  2. temperatureis maintained for approximately 1 hour
  3. filtrationThe solution is filtered when hot so
  4. additionthe filtrate is diluted with 1000 parts of water
  5. customthe precipitate formed
  6. customis isolated

출처 및 근거

ORD 기록
ord-fd18203542204cbcac75390e6de83719
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987027

반응 노트

불러오는 중…