Water → Ethyl (4Z)-8-oxo-4-octenoate

HRID 1288080노트

반응식

HRID 1288080 반응식
[OH:1][CH:2]1[CH2:9][CH2:8][CH:7]=[CH:6][CH2:5][CH2:4][C:3]1=[O:10].[CH2:11](O)[CH3:12].C1C=CC=CC=1.C([O-])(=[O:22])C.C([O-])(=O)C.C([O-])(=O)C.C([O-])(=O)C.[Pb+4].O>CCOCC>[O:10]=[CH:3][CH2:4][CH2:5]/[CH:6]=[CH:7]\[CH2:8][CH2:9][C:2]([O:1][CH2:11][CH3:12])=[O:22]

참가 물질

6

반응물 4

HCID 962WaterHCID 2737052-Hydroxy-5-cycloocten-1-oneHCID 21965192Npc112006HCID 178418268HCID 178418268, 화합물

생성물 1

HCID 24972431Ethyl (4Z)-8-oxo-4-octenoate

시약·촉매·용매 1

HCID 3283Diethyl Ether용매

실험 절차

To 220 mg. of 2-hydroxy-5-cycloocten-1-one in 5 ml. of 30% ethanol/benzene is added 860 mg. of 85% lead tetraacetate in portions. After about 3 hours at room temperature, water and ether are added to the reaction mixture. The aqueous phase is extracted several times with ether. The combined ether extracts are washed with 2M sodium carbonate and saturated sodium chloride solution, dried over calcium sulfate and evaporated to give ethyl (4Z)-8-oxo-4-octenoate in high purity.

후처리

  1. extractionThe aqueous phase is extracted several times with ether
  2. washThe combined ether extracts are washed with 2M sodium carbonate and saturated sodium chloride solution
  3. dry with materialdried over calcium sulfate
  4. customevaporated

출처 및 근거

ORD 기록
ord-67c0d37127484abe9efee17483f2e141
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03987073

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