methyl 4-(1-methyl-1H-indol-3-yl)butanoate → 4-(2-oxo-2,3-dihydro-1H-indol-3-yl)butanoic acid

반응식

[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[C:4]([CH2:11][CH2:12][CH2:13][C:14]([O:16]C)=[O:15])=[CH:3]1.CS(C)=[O:20].Cl>>[CH3:1][N:2]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]([CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])[C:3]1=[O:20].[O:20]=[C:3]1[CH:4]([CH2:11][CH2:12][CH2:13][C:14]([OH:16])=[O:15])[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[NH:2]1

참가 물질

반응물 2

HCID 3345143methyl 4-(1-methyl-1H-indol-3-yl)butanoate

HCID 12206146DMSO HCl

생성물 2

HCID 27640884-(2-oxo-2,3-dihydro-1H-indol-3-yl)butanoic acid

HCID 149562044-(1-Methyl-2-oxo-3-indolinyl)butanoic acid

실험 절차

Reaction of the ester [II: R1 =R3 =H, R2 =(CH2)3COOMe, R3 =Me] with DMSO/HCl as above gave crude 4-(1-methyl-2-oxo-3-indolinyl)butanoic acid [III: R1 =R3 =H, R2 =(CH2)3COOMe, R3 =Me] (0.84 g, 91% yield) as a brown oil.

출처 및 근거

ORD 기록: ord-fb7e125a62ab4aadb911826a54a70950
출처 데이터셋: uspto-grants-1995_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US05464861

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