Sodium Carbonate → 1-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

HRID 1288570노트

반응식

HRID 1288570 반응식
Cl[CH2:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[C:8]([CH3:13])[CH:9]=2)[CH:4]=1.C(=O)([O-])[O-].[Na+].[Na+].[N:20]1[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=1[N:26]1[CH2:31][CH2:30][NH:29][CH2:28][CH2:27]1>CN(C)C=O>[CH3:13][C:8]1[CH:9]=[C:10]2[C:5](=[CH:6][CH:7]=1)[CH:4]=[C:3]([CH2:2][N:29]1[CH2:30][CH2:31][N:26]([C:21]3[CH:22]=[CH:23][CH:24]=[CH:25][N:20]=3)[CH2:27][CH2:28]1)[CH:12]=[CH:11]2

참가 물질

5

반응물 3

HCID 10340Sodium CarbonateHCID 944591-(2-Pyridyl)piperazineHCID 133015572-(Chloromethyl)-6-methylnaphthalene

생성물 1

HCID 215029051-[(6-Methylnaphthalen-2-yl)methyl]-4-(pyridin-2-yl)piperazine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 11.0 g. of 2-chloromethyl-6-methylnaphthalene, 7.0 g. of sodium carbonate and 10.0 g. of 2-pyridylpiperazine in 75 ml. of dimethylformamide is stirred for six hours. The reaction mixture is cooled, filtered and the filtrate is concentrated. The precipitate is then washed with water and crystallized from ethanol to yield 1-(6-methyl-β-naphthylmethyl)-4-(2-pyridyl)piperazine.

후처리

  1. additionA mixture of 11.0 g
  2. temperatureThe reaction mixture is cooled
  3. filtrationfiltered
  4. concentrationthe filtrate is concentrated
  5. washThe precipitate is then washed with water
  6. customcrystallized from ethanol

출처 및 근거

ORD 기록
ord-f2b254025cd644c7b169da9058ff52bd
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03988457

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