Carbamimidoyl-acetic acid ethyl ester → 2,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester

HRID 1288586노트

반응식

HRID 1288586 반응식
[C:1]([C:6]1[CH:7]=[C:8]([CH:11]=[CH:12][CH:13]=1)[CH:9]=O)([O:3][CH2:4][CH3:5])=[O:2].[CH2:14]([O:16][C:17](=[O:22])[CH2:18][C:19](=[NH:21])[NH2:20])[CH3:15]>C(O)C>[CH2:14]([O:16][C:17]([C:18]1[CH:9]([C:8]2[CH:11]=[CH:12][CH:13]=[C:6]([C:1]([O:3][CH2:4][CH3:5])=[O:2])[CH:7]=2)[C:18]([C:17]([O:16][CH2:14][CH3:15])=[O:22])=[C:19]([NH2:20])[NH:21][C:19]=1[NH2:20])=[O:22])[CH3:15]

참가 물질

4

반응물 2

HCID 4599837Carbamimidoyl-acetic acid ethyl esterHCID 11084437Ethyl 3-formylbenzoate

생성물 1

HCID 706316882,6-Diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester수율 32%

시약·촉매·용매 1

HCID 702Ethanol용매2회

실험 절차

Upon boiling a solution of 8.9 g 3-carbethoxybenzaldehyde and 13.0 g amidinoacetic acid ethyl ester in 100 ml ethanol for 2 hours, 2,6-diamino-4-(3-carbethoxyphenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid diethyl ester of m.p. 191° C (ethanol) is obtained.

후처리

  1. customfor 2 hours

출처 및 근거

ORD 기록
ord-4a581bcb4f5a4ceaa0984d75c3f0b856
출처 데이터셋
uspto-grants-1976_10
특허 번호
US03988458

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