Formaldehyde → Methylglyoxal

HRID 1288662

반응식

HRID 1288662 반응식
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].C=O.C(C(/C=C\C(O)=O)=O)C(CC(O)=O)=[O:25].ClC(Cl)(Cl)C(C1C=CC(Cl)=CC=1)C1C=CC(Cl)=CC=1>>[CH3:6][C:2]([CH:3]=[O:5])=[O:25].[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4]

참가 물질

6

반응물 4

HCID 712FormaldehydeHCID 30361-Chloro-4-(2,2,2-trichloro-1-(4-chlorophenyl)ethyl)benzeneHCID 124886GlutathioneHCID 52803934-Maleylacetoacetic acid

생성물 2

HCID 880MethylglyoxalHCID 124886Glutathione

실험 절차

Glutathione functions as a co-enzyme for formaldehyde dehydrogenase, maleylacetoacetate isomerase, glyoxalase, prostaglandin endoperoxidase isomerases, and dichlorodiphenyltrichloroethane dehydrochlorinase and similar enzymes. In the glyoxalase reaction, the hemimercaptal formed nonenzymatically by reaction of methylglyoxal and glutathione (GSH) is converted by glyoxalase I to S-lactyl-Glutathione, which is split by glyoxalase II to D-lactate and Glutathione. In the formaldehyde dehydrogenase reaction, S-formyl Glutathione is formed (Glutathione+HCHO+NAD+) and hydrolyzed to formate and Glutathione.

후처리

  1. customIn the glyoxalase reaction

출처 및 근거

ORD 기록
ord-20f240749d8c4433b23b4769c315dad3
출처 데이터셋
uspto-grants-1998_05
특허 번호
US05747329

연결된 노트

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