Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Piperidine → 1-(Quinoxalin-6-ylcarbonyl)piperidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Piperidine | HCID 8082 | — |
| 반응물 | Quinoxaline-6-carboxylic acid | HCID 674813 | — |
| 반응물 | Bis-(1H-imidazol-2-YL)-methanone | HCID 5250894 | — |
| 반응물 | 1-(Quinoxalin-6-ylcarbonyl)-1,2,3,6-tetrahydropyridine | HCID 11630079 | — |
| 생성물 | 1-(Quinoxalin-6-ylcarbonyl)piperidine | HCID 148184 | — |
반응 단계
The coupling of 6-quinoxalinecarboxylic acid to piperidine is accomplished in a manner similar to that used for the preparation of Invention Compound XIII, or by any other method known in the art for activation of aromatic carboxylic acids, such as, for example, activation by carbonyl diimidazole. 1H NMR δ 1.56 and 1.73 (br, 6), 3.40 (br s, 2), 3.79 (br s, 2), 7.82 (dd, 1, J=8.8, 1.9 Hz), 8.13 (d, 1, J=1.6 Hz), 8.17 (d, 1, 8.6 Hz), and 8.9 ppm (m, 2).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05747492 |
| 출처 데이터셋 | uspto-grants-1998_05 |
| ORD ID | ord-ab7e10cc25434bebb2a8acef9509be19 |
| 출처 메모 | uspto-grants-1998_05 |